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Feeling anxious about your heartbeat can make palpitations worse

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Retatrutide is a newer weight loss medication that targets multiple hormone receptorsGLP-1, GIP, and glucagoncompared to semaglutide, which only targets GLP-1

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It is also possible that chronic GIP receptor agonism promotes receptor desensitisation or a biased agonism effect that gives rise to functional suppression of GIP activity and enhanced GLP-1 activity [49, 51]

The SURMOUNT clinical trial program, which supported FDA approval, included cardiovascular safety monitoring across more than 5,000 participants